Newswise — Oak Brook, IL – Volume 38 of SLAS Technology contains one evaluate, three technical briefs, 9 unique analysis articles, two literature highlights, and 7 entries from Special Issues on Revolutionizing Transcriptomics from Single-Cell Insights to RNA-Based Interventions and Bio-Inspired Computing and Machine Learning Analytics for a Future-Oriented Mental Well-Being.
Review
Technical Briefs
Original Research
- Diffusion Tensor Imaging (DTI) Combined with Diffusion Tensor Tractography (DTT) in the Brain Function and Volumetric Imaging in Children with Autism
A examine combining DTI and DTT in over 600 kids with autism reveals vital microstructural abnormalities in key white matter pathways, together with the corpus callosum and inside capsule, in comparison with wholesome controls. - A Method for the Evaluation of Automated Solid Dosing Technologies for Mid-Scale Dosing Tasks in Laboratory Automation
This examine investigates the necessities for automated stable dosing in biotechnological laboratories and introduces a technique for assessing off-the-shelf applied sciences to deal with a essential hole in laboratory automation, thereby decreasing handbook dealing with dangers and bettering effectivity in routine biotech workflows. - Continuous Evolving Humanoid for Advanced Cellular Models
The authors introduce “Maholo LabDroid,” an optimized humanoid robotic system for long-term iPSC tradition and organoid technology, integrating real-time imaging and versatile liquid dealing with to enhance scientific final result predictivity. - Experience from an HTS Campaign: Investigation of Susceptibility and Rescue of SARS-CoV-2 nsp3 Protease Assay from Metal Contamination
A high-throughput display discovers that copper and palladium contamination prompted false-positive hits in SARS-CoV-2 nsp3 protease screens, highlighting the essential significance of sturdy counter-screens to keep away from wasted assets in drug discovery. - Development and Validation of a Novel Ion-Pair Hydrophilic Interaction Liquid Chromatography Method for the Separation and Quantification of Oligonucleotide Therapeutics
The authors develop and optimize an ion-pair hydrophilic interplay liquid chromatography (IP-HILIC) system reaching baseline separation of 20–30-mer oligonucleotide therapeutics with superior decision and peak symmetry in comparison with conventional strategies. - Identification of a Telomere-Aging-Related Gene as a Novel Prognostic Factor for Intrahepatic Cholangiocarcinoma: Machine Learning-Aided Biomarker Discovery and Experimental Verification
Researchers assemble a prognostic danger mannequin for intrahepatic cholangiocarcinoma utilizing 4 telomere- and aging-related genes—BET1L, RAD50, ANXA1, and AURKA—that display excessive accuracy in predicting affected person outcomes. - Development of a Novel Fluid Removal System to Increase Throughput and Uniformity of Fluid Exchange in an Open Microfluidic Culture Platform
This article describes the Stacks Insert System, a novel fluid-removal gadget that reduces change time by greater than 14-fold and improves quantity uniformity in comparison with standard handbook pipetting on the Stacks open microfluidic cell tradition platform. The easy, adaptable accent enhances effectivity and reproducibility for ultra-low-volume fluid exchanges, with potential functions throughout different microfluidic and tissue chip techniques. - Self-Organized Anteroposterior Regionalization of Early Midbrain and Hindbrain/Spinal Cords Using Micropatterned Human Pluripotent Stem Cells
This analysis article demonstrates that micropatterned human pluripotent stem cells self-organize into anterior-posterior mind areas by way of BMP/Noggin dynamics, offering a speedy teratogen screening software. - GPT-Enhanced Robotic Automation Platform with User-Friendly Instruction Framework for Versatile Applications
The authors develop a common laboratory automation platform that mixes a standardized instruction framework for controlling multi-brand robots with a zero-code pure language interface powered by OpenAI’s GPTs, permitting scientists to automate complicated workflows utilizing easy textual content instructions. Their system affords a sensible, accessible answer for multi-robot automation with out requiring programming experience.
Literature Highlights
- Life Sciences and Accountability
This entry in the Life Sciences and Society sequence by SLAS Technology Associate Editor Kerstin Thurow, PhD, examines the intrinsic stress between scientific progress and accountability in the life sciences, arguing that accountability should be understood as a cultural and moral compass reasonably than a bureaucratic brake. - Literature Highlights Column: From the Literature
The authors spotlight a number of articles contributing to advances in biotechnology, AI in science, and nanotechnology.
Special Issues
- Revolutionizing Transcriptomics from Single-Cell Insights to RNA-Based Interventions
This Special Issue on techniques genetics examines gene and molecular interplay networks, using high-throughput sequencing and multi-omics applied sciences to know how genetic networks affect phenotypes. It emphasizes the importance of personalised drugs, therapeutic goal discovery and biomarker identification via built-in genomic and epigenomic approaches. - Bio-Inspired Computing and Machine Learning Analytics for a Future-Oriented Mental Well-Being
The Special Issue proposes bio-inspired computing and machine studying analytics for psychological well-being in the sector of life sciences innovation. Featured analysis reinforces the purpose of revolutionizing the supply of organic providers via a medical assistive atmosphere and facilitating the unbiased dwelling of sufferers.
All lively SLAS Discovery and SLAS Technology name for papers can be found at: https://www.slas.org/publications/call-for-papers/
This quantity of SLAS Technology is accessible at https://www.slas-technology.org/issue/S2472-6303(26)X2001-5
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SLAS Technology reveals how scientists adapt technological developments for all times sciences exploration and experimentation in biomedical analysis and improvement. The journal emphasizes scientific and technical advances that allow and enhance:
- Life sciences analysis and improvement
- Drug supply
- Diagnostics
- Biomedical and molecular imaging
- Personalized and precision drugs
SLAS (Society for Laboratory Automation and Screening) is a world skilled society of educational, trade and authorities life sciences researchers and the builders and suppliers of laboratory automation know-how. The SLAS mission is to deliver collectively researchers in academia, trade and authorities to advance life sciences discovery and know-how by way of schooling, data change and international neighborhood constructing.
SLAS Technology: Translating Life Sciences Innovation, 2025 Impact Factor 3.7. Editor-in-Chief Edward Kai-Hua Chow, PhD, KYAN Technologies, Los Angeles, CA (USA).
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