Data Skrive

In Week 5 of the 2025 NFL season, how many underdogs brought home the victory? Below, we provide a complete list of the teams that pulled off an upset last week.

Read more about last week’s NFL games on FOX Sports!

NFL Week 5’s Biggest Upsets

49ers 26, Rams 23

  • Spread: Rams -8.5
  • Total: Over (43.5)
  • Moneyline: Rams -450, 49ers +350

  • Spread: Bills -8
  • Total: Under (49.5)
  • Moneyline: Bills -450, Patriots +350

  • Spread: Eagles -4
  • Total: Under (44)
  • Moneyline: Eagles -225, Broncos +185

  • Spread: Chiefs -3.5
  • Total: Over (45.5)
  • Moneyline: Chiefs -200, Jaguars +165

  • Spread: Seahawks -3.5
  • Total: Over (44.5)
  • Moneyline: Seahawks -190, Buccaneers +155

  • Spread: Chargers -3
  • Total: Under (47.5)
  • Moneyline: Chargers -165, Commanders +140

  • Spread: Dolphins -1
  • Total: Over (44.5)
  • Moneyline: Dolphins -118, Panthers -102

FOX Sports created this story utilizing expertise offered by Data Skrive and knowledge from Sportradar.

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