On November 24, 2025, the President launched the Genesis Mission, a nationwide effort to speed up synthetic intelligence (AI) functions for transformative scientific discovery and deal with urgent nationwide challenges. This initiative will set up an built-in AI platform leveraging a long time of Federal funding on the earth’s largest assortment of scientific datasets to coach basis fashions and create AI brokers. Led by the Assistant to the President for Science and Technology and carried out by the Secretary of Energy inside the Department of Energy, the Genesis Mission goals to dramatically speed up scientific breakthroughs, strengthen nationwide safety, and additional America’s technological dominance.
Launching the Genesis Mission
The Genesis Mission was launched through Executive Order on November 24, 2025, establishing a nationwide effort to speed up scientific discovery utilizing synthetic intelligence. This initiative goals to deal with challenges comparable in urgency to the Manhattan Project, specializing in AI-enabled science to drive innovation and keep American technological dominance. The mission will leverage Federal scientific datasets – the world’s largest assortment – to coach AI basis fashions and create brokers for speculation testing and analysis automation.
The Secretary of Energy is chargeable for implementing the Genesis Mission inside the Department of Energy, integrating all related assets right into a safe, unified platform. Within 90 days of the order, the Secretary should establish accessible Federal computing, storage, and networking assets, together with each on-premises and cloud-based high-performance programs. Within 120 days, a plan for incorporating datasets from numerous sources—federally funded analysis, businesses, and personal companions—should be developed, prioritizing cybersecurity.
The American Science and Security Platform will function the infrastructure for the Genesis Mission, offering high-performance computing, AI modeling frameworks, and safe entry to datasets. The Secretary should assessment capabilities throughout DOE nationwide laboratories for robotic amenities able to AI-directed experimentation inside 240 days. An preliminary working functionality of the Platform, targeted on at the least one nationwide problem, is to be demonstrated inside 270 days.
Establishment of the Genesis Mission
The Genesis Mission was formally established through Executive Order on November 24, 2025, as a nationwide effort to speed up scientific discovery utilizing synthetic intelligence. This initiative goals to deal with urgent nationwide challenges by leveraging the world’s largest assortment of Federal scientific datasets. The mission’s focus is on AI-enabled science, mirroring the ambition of tasks just like the Manhattan Project, and intends to strengthen nationwide safety, power dominance, and workforce productiveness by way of technological development.
The Secretary of Energy is chargeable for implementing the Genesis Mission inside the Department of Energy, integrating all related assets right into a safe, unified platform. Within 90 days of the order, the Secretary should establish accessible Federal computing assets, together with each on-premises and cloud-based high-performance computing programs. A plan for incorporating datasets from numerous sources—federally funded analysis, businesses, academia, and authorised personal companions—is due inside 120 days, prioritizing cybersecurity measures.
A core element of the Genesis Mission is the American Science and Security Platform, designed to offer built-in entry to high-performance computing, AI modeling frameworks, and domain-specific basis fashions. Within 270 days of the order, the Secretary will assessment capabilities throughout DOE nationwide laboratories for robotic amenities able to AI-directed experimentation and manufacturing. The mission will initially give attention to at the least 20 science and expertise challenges, spanning areas like superior manufacturing and biotechnology.
From the founding of our Republic, scientific discovery and technological innovation have pushed American progress and prosperity.
Operation of the American Science and Security Platform
The Genesis Mission establishes the American Science and Security Platform to perform as its core infrastructure. This Platform will combine a number of key assets, together with high-performance computing – using DOE nationwide laboratory supercomputers and safe cloud environments – and AI modeling frameworks. Access to various datasets—proprietary, federally curated, and open—will probably be central, alongside AI-enabled predictive fashions and instruments for autonomous experimentation and manufacturing, all whereas adhering to authorized and safety requirements.
Within 90 days of the order, the Secretary of Energy should establish present federal computing, storage, and networking assets—each on-premises and cloud-based—to assist the Mission. Further investigation will even goal potential partnerships and infrastructure enhancements. Within 120 days, preliminary knowledge and mannequin belongings will probably be recognized, specializing in digitization, standardization, and monitoring their origin, alongside a plan for incorporating datasets from numerous sources with strong cybersecurity measures.
To show preliminary working functionality inside 270 days, the Secretary will assess DOE nationwide laboratories and amenities for robotic and manufacturing capabilities appropriate for AI-directed experimentation. The Platform goals to deal with at the least 20 nationwide science and expertise challenges – spanning areas like superior manufacturing, biotechnology, and quantum info science – recognized in coordination with the Assistant to the President for Science and Technology.
Identifying National Science and Technology Challenges
The Genesis Mission, established through Executive Order, straight addresses figuring out nationwide science and expertise challenges. Within 60 days of the order (November 24, 2025), the Secretary of Energy is tasked with submitting an in depth checklist of at the least 20 such challenges. These challenges ought to align with precedence domains outlined in National Science and Technology Memorandum 2, dated September 23, 2025, to the Assistant to the President for Science and Technology (APST).
The APST will then assessment the Secretary’s checklist and, collaborating with businesses by way of the National Science and Technology Council (NSTC), create an expanded checklist. This expanded checklist will function the preliminary focus for the Genesis Mission’s efforts. Priority domains for these challenges embrace superior manufacturing, biotechnology, vital supplies, nuclear power (fission and fusion), quantum info science, and semiconductors/microelectronics.
The final objective of the Genesis Mission is to speed up options to those recognized challenges. This will probably be achieved by way of the American Science and Security Platform, offering entry to high-performance computing, AI modeling frameworks, and safe datasets. Within 270 days of the order, the Secretary goals to show preliminary working functionality of the Platform for at the least considered one of these nationwide science and expertise challenges.
This order launches the “Genesis Mission” as a devoted, coordinated nationwide effort to unleash a brand new age of AI‑accelerated innovation and discovery that may resolve essentially the most difficult issues of this century.
Secretarial Responsibilities for Implementation
The Secretary of Energy is assigned main accountability for implementing the Genesis Mission inside the Department of Energy (DOE). This contains setting priorities and integrating all DOE assets used for the Mission right into a safe, unified platform. The Secretary may additionally designate a senior political appointee to supervise each day operations. Within 90 days of the order, the Secretary should establish accessible federal computing, storage, and networking assets, together with each on-premises and cloud-based programs, to assist the Mission’s infrastructure.
Within 120 days of the order, the Secretary will establish preliminary knowledge and mannequin belongings to be used within the Mission, specializing in digitization, standardization, and monitoring knowledge origins. A plan will probably be developed, with cybersecurity measures, for incorporating datasets from federally funded analysis, businesses, universities, and personal companions, as applicable. This work establishes the inspiration for the American Science and Security Platform, which can present entry to high-performance computing and AI modeling instruments.
The Secretary can also be tasked with reviewing capabilities throughout DOE nationwide laboratories and different amenities for robotic laboratories and manufacturing amenities able to AI-directed experimentation and manufacturing inside 240 days of the order. This assessment focuses on automated workflows and associated technical requirements. Within 270 days, the Secretary goals to show an preliminary working functionality of the Platform, addressing at the least one nationwide science and expertise problem.
Platform Infrastructure and Resource Development
The Genesis Mission establishes the American Science and Security Platform as its core infrastructure. This Platform will combine high-performance computing assets, together with DOE nationwide laboratory supercomputers and safe cloud environments, to assist large-scale AI mannequin coaching. It will even incorporate AI modeling frameworks, computational instruments like predictive fashions, and domain-specific basis fashions. Secure entry to various datasets – federally curated, proprietary, and open – is central to the Platform’s design, adhering to all related authorized and safety requirements.
Within 90 days of the order, the Secretary of Energy is tasked with figuring out accessible Federal computing, storage, and networking assets for the Mission, encompassing each on-premises and cloud-based programs, in addition to potential trade partnerships. Following that, inside 120 days, a plan will probably be developed to include datasets from federally funded analysis, businesses, and authorised personal companions, prioritizing risk-based cybersecurity measures.
The Platform’s capabilities will even lengthen to experimental and manufacturing instruments, enabling AI-directed experimentation and manufacturing in key domains. A assessment of robotic laboratories and manufacturing amenities throughout DOE nationwide laboratories is remitted inside 240 days, targeted on automated workflows and mandatory technical requirements. An preliminary working functionality for at the least one nationwide problem is focused inside 270 days, demonstrating the Platform’s potential.