IMAGE: Professor Youhong Tang, Flinders University
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Credit: Flinders University

A novel option to pinpoint and illuminate bone damage guarantees to make X-rays extra environment friendly at diagnosing bone and different accidents, Flinders University researchers say.

The new method, potential biomedical purposes of an historic inorganic salt-based aggregation induced emission (AIE) radio-luminescence materials, may open new frontiers in drugs together with X-ray dosimetry, bioimaging and superior purposes similar to optogenetics, says Professor Youhong Tang, from Flinders University’s College of Science and Engineering.

The assessment article, printed by Professor Tang, postdoctoral scholar Dr Javad Tavokoli, colleagues in Hong Kong and Australian know-how firm Micro-X and, examined the potential of the AIEgen luminogens (AIEgens) in deep tissue imaging. The study used X-ray testing supplied by Adelaide-based Micro-X.

“We were able to use Micro-X advanced X-ray machines at the Tonsley Innovation District to show the benefits of this AIEgen system which can be excited by X-ray (as the radioluminescence emitter) and UV light (as the photoluminescence emitter) compared to current AIEgens which mostly only act as the photoluminescence emitter,” he says.

“The study highlighted the disadvantages of autofluorescence, poor signal-to-noise radio, and poor tissue penetration depth of traditional photoluminescence emitters which could be elegantly solved by these radioluminescence luminogens,” says Professor of Mechanical and Materials Engineering, Dr Tang.

“Not only do they pinpoint bone and soft tissue damage for better diagnosis and treatment but we suggest further studies could see these AIE-based materials with multifunctionalities used for improved drug delivery, biosensors, bioimaging, and tissue engineering.”

Lead writer on the journal article in Aggregate, Dr Tavokoli, how based mostly on the Centre for Health Technologies at University of Technology Sydney, says the following era of fluorescent gels may additionally capitalise on further light-emitting properties making them enticing for various purposes.

The newest work not solely explores a collection of inorganic AIE techniques but in addition “basically helps to grasp each the unconventional natural and inorganic clusteroluminescence phenomena, Professor Tang concludes.


The paper, Revisiting an historic inorganic aggregation?induced emission system: An enlightenment to clusteroluminescence (2021) by Zheng Zhao, Zaiyu Wang, Javad Tavakoli, Guogang Shan, Jianyu Zhang, Chen Peng, Yu Xiong, Xuepeng Zhang, Tsz Shing Cheung, Youhong Tang, Bolong Huang and Zhaoxun Yu printed in Aggregate DOI: 10.1002/agt2.36

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